TrueCrypt is better for files since it cannot decrypt already encrypted disks. TrueCrypt encrypted files can be accessed in Linux.

http://www.truecrypt.org/
http://en.wikipedia.org/wiki/TrueCrypt 

DiskCryptor is better for encrypting disks. DiskCryptor encrypted disks cannot be accessed in Linux.

http://diskcryptor.net/wiki/Main_Page
http://en.wikipedia.org/wiki/DiskCrypto

IMSIDBB8A4092816BF811F0804E7F586A5601ED1365A8